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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737354
Species: Homo sapiens
RGD Object: Gene
Symbol: F3
Name: coagulation factor III, tissue factor
Acc ID: CHEBI:17627
Term: ferroheme b
Definition: Heme b in which the iron has oxidation state +2.
Chemical ID: MESH:D006418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F3increases expressionEXP 6480464CTDHeme results in increased expression of F3 mRNAPMID:18983524
F3multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]PMID:18983524
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