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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68573
Species: Mus musculus
RGD Object: Gene
Symbol: Alas1
Name: aminolevulinic acid synthase 1
Acc ID: CHEBI:17627
Term: ferroheme b
Definition: Heme b in which the iron has oxidation state +2.
Chemical ID: MESH:D006418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alas1decreases expressionISOALAS1 (Homo sapiens)6480464CTDHeme results in decreased expression of ALAS1 proteinPMID:21659532
Alas1multiple interactionsISOALAS1 (Homo sapiens)6480464CTDMG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]PMID:21659532
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