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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:17620
Term: ferulic acid
Definition: A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.
Chemical ID: MESH:C004999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2decreases expressionEXP 6480464CTDferulic acid results in decreased expression of PTGS2 proteinPMID:15841493
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]PMID:18068289
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDferulic acid analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]PMID:17436566 PMID:21291945
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