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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2783
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hbb
Name: hemoglobin subunit beta
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hbbdecreases methylationISOHBB (Homo sapiens)6480464CTDhydroquinone results in decreased methylation of HBB promoterPMID:23973255
Hbbmultiple interactionsISOHBB (Homo sapiens)6480464CTDDecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; hydroquinone promotes the reaction [GATA2 protein binds to HBB gene]PMID:21414390 PMID:23973255 PMID:37329354
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