GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | affects expression | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | hydroquinone affects the expression of SIRT1 mRNA; hydroquinone affects the expression of SIRT1 protein | PMID:27515134 | Sirt1 | affects response to substance | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | SIRT1 protein affects the susceptibility to hydroquinone | PMID:27515134 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | [SIRT1 protein affects the susceptibility to hydroquinone] which affects the expression of H2AX protein; SIRT1 protein affects the reaction [hydroquinone results in increased expression of CDKN1A protein]; SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of ATG5 mRNA]; SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of BECN1 mRNA] | PMID:27515134 PMID:28263894 | | ||||||||||||||||||||||
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