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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1298347
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP7
Name: caspase 7
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP7decreases activityEXP 6480464CTDhydroquinone results in decreased activity of CASP7 proteinPMID:22960397
CASP7increases cleavageEXP 6480464CTDhydroquinone results in increased cleavage of CASP7 proteinPMID:19064679
CASP7increases expressionEXP 6480464CTDhydroquinone results in increased expression of CASP7 protein modified formPMID:28886972
CASP7multiple interactionsEXP 6480464CTDLithium Chloride inhibits the reaction [hydroquinone results in increased expression of CASP7 protein modified form]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein]PMID:19064679 PMID:28886972
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