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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases cleavageEXP 6480464CTDhydroquinone results in decreased cleavage of IL1B proteinPMID:9118901
Il1bdecreases secretionEXP 6480464CTDhydroquinone results in decreased secretion of IL1B proteinPMID:8548860
Il1bmultiple interactionsEXP 6480464CTD[KMT2A mutant form results in decreased susceptibility to hydroquinone] which results in increased expression of IL1B mRNA; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]PMID:17464197 PMID:19148301 PMID:37245849
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDhydroquinone results in increased expression of IL1B mRNAPMID:31256213
Il1bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTD[COL2A1 protein co-treated with Freund's Adjuvant co-treated with hydroquinone] results in increased secretion of IL1B protein; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]PMID:22717997 PMID:29908986
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased expression of and results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of and results in increased secretion of IL1B protein]; hydroquinone results in increased expression of and results in increased secretion of IL1B proteinPMID:36646296
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