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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10730
Species: Mus musculus
RGD Object: Gene
Symbol: Hras
Name: Harvey rat sarcoma virus oncogene
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrasaffects expressionISOHRAS (Homo sapiens)6480464CTDhydroquinone affects the expression of HRAS mRNA; hydroquinone affects the expression of HRAS proteinPMID:26047893
Hrasmultiple interactionsISOHRAS (Homo sapiens)6480464CTD3-aminobenzamide inhibits the reaction [hydroquinone results in increased expression of HRAS protein]; Doxorubicin inhibits the reaction [hydroquinone results in decreased expression of HRAS protein]; hydroquinone promotes the reaction [PARP1 protein binds to and results in increased ADP-ribosylation of and results in increased expression of HRAS protein]; PARP1 protein promotes the reaction [hydroquinone results in increased expression of HRAS protein]PMID:26047893
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