Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10596
Species: Mus musculus
RGD Object: Gene
Symbol: Fos
Name: FBJ osteosarcoma oncogene
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDhydroquinone results in decreased expression of FOS mRNAPMID:15452088
Fosincreases phosphorylationISOFOS (Homo sapiens)6480464CTDhydroquinone results in increased phosphorylation of FOS proteinPMID:23791922
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [hydroquinone results in increased phosphorylation of FOS protein]; FOS protein affects the reaction [hydroquinone results in decreased expression of MIR122 mRNA]; FOS protein affects the reaction [hydroquinone results in increased expression of ADAM17 mRNA]; FOS protein affects the reaction [hydroquinone results in increased expression of ADAM17 protein]; hydroquinone promotes the reaction [FOS protein binds to MIR122 promoter]PMID:23791922
Go Back to source page   Continue to Ontology report