GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fos | decreases expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | hydroquinone results in decreased expression of FOS mRNA | PMID:15452088 | Fos | increases phosphorylation | ISO | FOS (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased phosphorylation of FOS protein | PMID:23791922 | Fos | multiple interactions | ISO | FOS (Homo sapiens) | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [hydroquinone results in increased phosphorylation of FOS protein]; FOS protein affects the reaction [hydroquinone results in decreased expression of MIR122 mRNA]; FOS protein affects the reaction [hydroquinone results in increased expression of ADAM17 mRNA]; FOS protein affects the reaction [hydroquinone results in increased expression of ADAM17 protein]; hydroquinone promotes the reaction [FOS protein binds to MIR122 promoter] | PMID:23791922 | |
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