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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735455
Species: Mus musculus
RGD Object: Gene
Symbol: mt-Co3
Name: cytochrome c oxidase III, mitochondrial
Acc ID: CHEBI:175901
Term: gemcitabine
Definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Chemical ID: MESH:C056507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
mt-Co3decreases response to substanceISOMT-CO3 (Homo sapiens)6480464CTDCOX3 protein results in decreased susceptibility to GemcitabinePMID:17428446
mt-Co3multiple interactionsISOMT-CO3 (Homo sapiens)6480464CTDSodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to Gemcitabine]PMID:17428446
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