GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Trp53 | affects activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Gemcitabine affects the activity of TP53 protein | PMID:35435491 | Trp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Gemcitabine results in increased expression of TP53 protein | PMID:12082016 PMID:16601104 PMID:17671697 | Trp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein] | PMID:16601104 PMID:21489314 | |
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