Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1344840
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	ACOX1
Name:	acyl-CoA oxidase 1

Acc ID:	CHEBI:17580
Term:	linalool
Definition:	A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.
Chemical ID:	MESH:C018584

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
ACOX1	increases expression	EXP		6480464	CTD	linalool results in increased expression of ACOX1 mRNA; linalool results in increased expression of ACOX1 protein	PMID:24752549
ACOX1	multiple interactions	EXP		6480464	CTD	PPARA protein promotes the reaction [linalool results in increased expression of ACOX1 protein]	PMID:24752549
ACOX1	increases expression	ISO	Acox1 (Mus musculus)	6480464	CTD	linalool results in increased expression of ACOX1 mRNA; linalool results in increased expression of ACOX1 protein	PMID:24752549
ACOX1	multiple interactions	ISO	Acox1 (Mus musculus)	6480464	CTD	PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 protein]	PMID:24752549

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