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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736765
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1B1
Name: cytochrome P450 family 1 subfamily B member 1
Acc ID: CHEBI:17574
Term: biochanin A
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Chemical ID: MESH:C004541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1B1decreases methylationEXP 6480464CTDCYP1B1 protein results in decreased methylation of biochanin APMID:15479032
CYP1B1increases expressionEXP 6480464CTDbiochanin A results in increased expression of CYP1B1 mRNAPMID:28985473 PMID:31621310
CYP1B1multiple interactionsEXP 6480464CTDAHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]PMID:31621310
CYP1B1increases expressionISOCyp1b1 (Mus musculus)6480464CTDbiochanin A results in increased expression of CYP1B1 mRNAPMID:31621310
CYP1B1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTDSodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]PMID:31621310
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