Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731081
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	PGR
Name:	progesterone receptor

Acc ID:	CHEBI:17574
Term:	biochanin A
Definition:	A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Chemical ID:	MESH:C004541

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
PGR	affects binding	EXP		6480464	CTD	biochanin A binds to PGR protein	PMID:14579009
PGR	increases expression	EXP		6480464	CTD	biochanin A results in increased expression of PGR mRNA	PMID:16076101
PGR	multiple interactions	EXP		6480464	CTD	biochanin A inhibits the reaction [Progesterone binds to PGR protein]	PMID:14579009
PGR	increases expression	ISO	Pgr (Rattus norvegicus)	6480464	CTD	biochanin A results in increased expression of PGR mRNA	PMID:34848279
PGR	multiple interactions	ISO	Pgr (Rattus norvegicus)	6480464	CTD	Fulvestrant inhibits the reaction [biochanin A results in increased expression of PGR mRNA]	PMID:34848279

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