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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730988
Species: Homo sapiens
RGD Object: Gene
Symbol: VCAM1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:17574
Term: biochanin A
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Chemical ID: MESH:C004541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VCAM1decreases expressionISOVcam1 (Rattus norvegicus)6480464CTDbiochanin A results in decreased expression of VCAM1 proteinPMID:16223672 PMID:16735947
VCAM1multiple interactionsISOVcam1 (Rattus norvegicus)6480464CTDbiochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein]PMID:16223672 PMID:16735947
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