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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:17574
Term: biochanin A
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Chemical ID: MESH:C004541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases methylationISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in decreased methylation of biochanin APMID:15479032
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTDbiochanin A results in increased activity of CYP1A1 proteinPMID:16903077
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDbiochanin A results in increased expression of CYP1A1 mRNAPMID:16903077 PMID:28985473 PMID:31621310
Cyp1a1increases hydroxylationISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased hydroxylation of biochanin APMID:15479032
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDAHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]PMID:16903077 PMID:28985473 PMID:31621310
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