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RGD ID: 2465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2a3
Name: cytochrome P450, family 2, subfamily a, polypeptide 3
Acc ID: CHEBI:17549
Term: 5-aminolevulinic acid
Definition: The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Chemical ID: MESH:D000622
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a3increases expressionISORGD:7318676480464CTDAminolevulinic Acid results in increased expression of CYP2A5 mRNAPMID:22859313
Cyp2a3multiple interactionsISORGD:7318676480464CTDNFE2L2 gene mutant form inhibits the reaction [Aminolevulinic Acid results in increased expression of CYP2A5 mRNA]PMID:22859313
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