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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345686
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
Acc ID: CHEBI:17500
Term: 7alpha-hydroxycholesterol
Definition: The 7alpha-hydroxy derivative of cholesterol.
Chemical ID: MESH:C011724
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL8increases expressionEXP 6480464CTDcholest-5-en-3 beta,7 alpha-diol results in increased expression of CXCL8 mRNAPMID:16142584 PMID:24802026
CXCL8increases secretionEXP 6480464CTDcholest-5-en-3 beta,7 alpha-diol results in increased secretion of CXCL8 proteinPMID:16142584
CXCL8multiple interactionsEXP 6480464CTD[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CXCL8 mRNA; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CXCL8 mRNA]; Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of CXCL8 mRNA]; Quercetin inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of CXCL8 mRNA]PMID:24802026
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