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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:17489
Term: 3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Chemical ID: MESH:D000242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA

PMID:8404651
affects secretionISORGD:13485906480464CTDCGA protein affects the secretion of Cyclic AMP

PMID:23071612
increases abundanceISORGD:13485906480464CTDCGA protein results in increased abundance of Cyclic AMP

PMID:20378682, PMID:21642635, PMID:31132478
multiple interactionsISORGD:13485906480464CTD[CGA protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone, [CGA protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP, [CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP, Colforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP], DDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]

PMID:20378682, PMID:23071612, PMID:26895433
multiple interactionsISORGD:7318386480464CTD[ESR2 gene mutant form results in decreased expression of LHCGR protein] inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP], Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]], ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]

PMID:20378682
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.