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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:17489
Term: 3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Chemical ID: MESH:D000242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:113506480464CTDCyclic AMP results in increased expression of STAR mRNA, Cyclic AMP results in increased expression of STAR protein

PMID:19822634, PMID:20100736, PMID:25576683, PMID:28668616
multiple interactionsISORGD:113506480464CTD[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein, Calcium inhibits the reaction [Cyclic AMP results in increased expression of STAR protein], Diltiazem promotes the reaction [Cyclic AMP results in increased expression of STAR protein], Isradipine promotes the reaction [Cyclic AMP results in increased expression of STAR protein], Mn(III) 5, 10, 15, 20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]], Mn(III) 5, 10, 15, 20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein]], myricetin promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein], N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein], Nifedipine promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA], perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA], perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein], quercetin pentaacetate promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA], Quercetin promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA], Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA], Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR protein]

PMID:19822634, PMID:20100736, PMID:28668616
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.