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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731579
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGCR
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:17447
Term: geraniol
Definition: A monoterpenoid consisting of two prenyl units linked head-to-tail and functionalised with a hydroxy group at its tail end.
Chemical ID: MESH:C007836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGCRaffects expressionEXP 6480464CTDgeraniol affects the expression of HMGCR mRNAPMID:23668785
HMGCRdecreases activityEXP 6480464CTDgeraniol results in decreased activity of HMGCR proteinPMID:12477733 PMID:15450939 PMID:16462894
HMGCRdecreases expressionEXP 6480464CTDgeraniol results in decreased expression of HMGCR proteinPMID:23668785 PMID:24875281
HMGCRdecreases expressionISOHmgcr (Mus musculus)6480464CTDgeraniol results in decreased expression of HMGCR proteinPMID:24875281 PMID:26141755
HMGCRincreases expressionISOHmgcr (Mus musculus)6480464CTDgeraniol results in increased expression of HMGCR mRNAPMID:26141755
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