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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:17447
Term: geraniol
Definition: A monoterpenoid consisting of two prenyl units linked head-to-tail and functionalised with a hydroxy group at its tail end.
Chemical ID: MESH:C007836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDgeraniol results in increased expression of CASP3 protein modified formPMID:26154255
Casp3multiple interactionsEXP 6480464CTDgeraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CASP3 protein]PMID:29050341
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDgeraniol results in increased activity of CASP3 proteinPMID:21371438 PMID:24875281
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDgeraniol results in increased expression of CASP3 mRNA; geraniol results in increased expression of CASP3 proteinPMID:30506710
Casp3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTD[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased cleavage of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA]; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CASP3 protein]; geraniol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]PMID:21907755 PMID:22509279 PMID:26165751 PMID:26364502 PMID:26695085 PMID:34343525
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