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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10511
Species: Mus musculus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrdecreases expressionISOEgfr (Rattus norvegicus)6480464CTD2-Acetylaminofluorene results in decreased expression of EGFR mRNAPMID:22213190
Egfrmultiple interactionsISOEgfr (Rattus norvegicus)6480464CTD2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]PMID:10900465
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