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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1multiple interactionsISOCyp7a1 (Rattus norvegicus)6480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNAPMID:14656948 PMID:16158176
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