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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:17351
Term: linoleic acid
Definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.
Chemical ID: MESH:D019787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects bindingEXP 6480464CTDLinoleic Acid binds to PPARG proteinPMID:12021203
Ppargincreases expressionEXP 6480464CTDLinoleic Acid results in increased expression of PPARG mRNAPMID:18154422
Ppargmultiple interactionsEXP 6480464CTDLinoleic Acid binds to and results in increased activity of PPARG proteinPMID:16731579
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDLinoleic Acid binds to PPARG proteinPMID:23843199 PMID:35752307
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDLinoleic Acid results in decreased expression of PPARG mRNA; Linoleic Acid results in decreased expression of PPARG proteinPMID:11172467 PMID:15708366
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDLinoleic Acid results in increased activity of PPARG proteinPMID:25786526
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDLinoleic Acid results in increased expression of PPARG proteinPMID:25672876
Ppargmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDLinoleic Acid binds to and results in increased activity of PPARG proteinPMID:16731579
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDresveratrol inhibits the reaction [Linoleic Acid results in increased expression of PPARG protein]PMID:25672876
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