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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:17351
Term: linoleic acid
Definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.
Chemical ID: MESH:D019787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6affects expressionEXP 6480464CTDLinoleic Acid affects the expression of IL6 proteinPMID:16305726
IL6increases secretionEXP 6480464CTDLinoleic Acid results in increased secretion of IL6 proteinPMID:21457203
IL6increases expressionISOIl6 (Mus musculus)6480464CTDLinoleic Acid results in increased expression of IL6 mRNAPMID:17374693
IL6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTDLinoleic Acid inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of IL6 mRNA]PMID:34111468
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