GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp17a1 | affects chemical synthesis | EXP | | 6480464 | CTD | CYP17A1 protein affects the chemical synthesis of Testosterone | PMID:15932923 | Cyp17a1 | decreases expression | EXP | | 6480464 | CTD | Testosterone results in decreased expression of CYP17A1 mRNA | PMID:20600201 PMID:21669218 | Cyp17a1 | multiple interactions | EXP | | 6480464 | CTD | [[titanium dioxide results in decreased expression of CYP17A1 mRNA] co-treated with [titanium dioxide results in decreased expression of HSD17B10 mRNA]] results in increased chemical synthesis of Testosterone; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA; [Lipopolysaccharides results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosterone; AMH protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Testosterone]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Tretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA] | PMID:14630719 PMID:22285649 PMID:24241477 PMID:8828518 | Cyp17a1 | affects abundance | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | CYP17A1 protein affects the abundance of Testosterone | PMID:21427057 | Cyp17a1 | decreases expression | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | Testosterone results in decreased expression of CYP17A1 mRNA | PMID:15625562 | Cyp17a1 | multiple interactions | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | [CYP17A1 gene SNP affects the susceptibility to perfluorooctane sulfonic acid] which affects the abundance of Testosterone | PMID:34536543 | Cyp17a1 | multiple interactions | ISO | Cyp17a1 (Rattus norvegicus) | 6480464 | CTD | [bisphenol A results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosterone; [bisphenol A results in increased expression of CYP17A1 mRNA] which affects the abundance of Testosterone; [prochloraz results in decreased activity of CYP17A1 protein] which results in decreased chemical synthesis of Testosterone | PMID:14605012 PMID:17234647 PMID:17369198 PMID:18191889 | | ||||||||||||||||||||||
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