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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732912
Species: Homo sapiens
RGD Object: Gene
Symbol: GNMT
Name: glycine N-methyltransferase
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GNMTincreases expressionEXP 6480464CTDTestosterone results in increased expression of GNMT mRNAPMID:21592394
GNMTmultiple interactionsEXP 6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of GNMT mRNAPMID:21592394
GNMTdecreases expressionISOGnmt (Mus musculus)6480464CTDTestosterone deficiency results in decreased expression of GNMT mRNAPMID:33848595
GNMTmultiple interactionsISOGnmt (Rattus norvegicus)6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of GNMT mRNA]PMID:20032058
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