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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2decreases expressionEXP 6480464CTDTestosterone results in decreased expression of ESR2 mRNA; Testosterone results in decreased expression of ESR2 proteinPMID:23500659 PMID:26492952 PMID:27866977
Esr2increases expressionEXP 6480464CTDTestosterone results in increased expression of ESR2 mRNAPMID:15917159
Esr2multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA]; Qing Ye Dan inhibits the reaction [Testosterone results in decreased expression of ESR2 protein]; Silymarin inhibits the reaction [Testosterone results in decreased expression of ESR2 protein]PMID:23500659 PMID:26492952 PMID:27866977
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDTestosterone binds to ESR2 proteinPMID:19913605 PMID:31836225
Esr2decreases expressionISOEsr2 (Mus musculus)6480464CTDTestosterone results in decreased expression of ESR2 proteinPMID:15916834
Esr2increases expressionISOEsr2 (Mus musculus)6480464CTDTestosterone results in increased expression of ESR2 mRNA; Testosterone results in increased expression of ESR2 proteinPMID:15916834 PMID:20844152
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