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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606342
Species: Homo sapiens
RGD Object: Gene
Symbol: FASLG
Name: Fas ligand
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASLGmultiple interactionsEXP 6480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with Testosterone] results in increased expression of FASLG mRNA; [Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with Testosterone] results in increased expression of FASLG proteinPMID:20529085
FASLGdecreases expressionISOFaslg (Rattus norvegicus)6480464CTDTestosterone deficiency results in decreased expression of FASLG proteinPMID:20850791
FASLGincreases expressionISOFaslg (Rattus norvegicus)6480464CTDTestosterone results in increased expression of FASLG mRNAPMID:24658017
FASLGmultiple interactionsISOFaslg (Rattus norvegicus)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased expression of FASLG mRNA]; Flutamide inhibits the reaction [Testosterone results in increased expression of FASLG mRNA]; Testosterone inhibits the reaction [Diethylstilbestrol results in increased expression of FASLG protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Testosterone results in increased expression of FASLG mRNA]PMID:12477725 PMID:24658017
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