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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348351
Species: Homo sapiens
RGD Object: Gene
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACTA2increases expressionEXP 6480464CTDTestosterone results in increased expression of ACTA2 mRNAPMID:21592394
ACTA2multiple interactionsEXP 6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of ACTA2 mRNAPMID:21592394
ACTA2increases expressionISOActa2 (Rattus norvegicus)6480464CTDTestosterone results in increased expression of ACTA2 mRNAPMID:27866977
ACTA2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTDFinasteride inhibits the reaction [Testosterone results in increased expression of ACTA2 mRNA]; Qing Ye Dan inhibits the reaction [Testosterone results in increased expression of ACTA2 mRNA]; swertiamarin inhibits the reaction [Testosterone results in increased expression of ACTA2 mRNA]PMID:27866977
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