GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2B6 | increases hydroxylation | EXP | | 6480464 | CTD | CYP2B6 protein results in increased hydroxylation of Testosterone | PMID:19833192 | CYP2B6 | increases metabolic processing | EXP | | 6480464 | CTD | CYP2B6 protein results in increased metabolism of Testosterone | PMID:12464242 | CYP2B6 | affects expression | ISO | Cyp2b10 (Mus musculus) | 6480464 | CTD | Testosterone affects the expression of CYP2B10 mRNA | PMID:7771797 | CYP2B6 | decreases activity | ISO | Cyp2b10 (Mus musculus) | 6480464 | CTD | Testosterone results in decreased activity of CYP2B10 protein | PMID:18420780 | CYP2B6 | decreases expression | ISO | Cyp2b10 (Mus musculus) | 6480464 | CTD | Testosterone results in decreased expression of CYP2B10 mRNA | PMID:11075820 PMID:21669218 | CYP2B6 | multiple interactions | ISO | Cyp2b10 (Mus musculus) | 6480464 | CTD | Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]] | PMID:24769335 | |
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