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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plk4
Name: polo-like kinase 4
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plk4multiple interactionsEXP 6480464CTDTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PLK4 mRNA]

PMID:20032058
Plk4decreases expressionISORGD:13133926480464CTDTestosterone results in decreased expression of PLK4 mRNA

PMID:21592394
Plk4multiple interactionsISORGD:13133926480464CTD[Testosterone co-treated with Calcitriol] results in decreased expression of PLK4 mRNA

PMID:21592394
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.