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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10812
Species: Mus musculus
RGD Object: Gene
Symbol: Ins2
Name: insulin II
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2decreases abundanceISOIns2 (Rattus norvegicus)6480464CTDINS protein results in decreased abundance of TestosteronePMID:28300557
Ins2increases expressionISOINS (Homo sapiens)6480464CTDTestosterone results in increased expression of INS proteinPMID:9851674
Ins2multiple interactionsISOIns2 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of INS2 mRNA; NR0B1 protein promotes the reaction [INS protein results in decreased abundance of Testosterone]PMID:26496021 PMID:28300557
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTDTestosterone promotes the reaction [INS protein results in decreased oxidation of Palmitates]; Testosterone promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]PMID:21632903
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