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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10766
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor I receptor
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rincreases expressionEXP 6480464CTDTestosterone results in increased expression of IGF1R mRNAPMID:21045173
Igf1rincreases expressionISOIgf1r (Rattus norvegicus)6480464CTDTestosterone results in increased expression of IGF1R mRNAPMID:26492952 PMID:29247772
Igf1rincreases expressionISOIGF1R (Homo sapiens)6480464CTDTestosterone results in increased expression of IGF1R mRNAPMID:21592394
Igf1rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTDchrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]; Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]PMID:26492952 PMID:29247772
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of IGF1R mRNAPMID:21592394
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