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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10734
Species: Mus musculus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1increases expressionEXP 6480464CTDTestosterone results in increased expression of HSD11B1 mRNAPMID:19693291
Hsd11b1increases activityISOHSD11B1 (Homo sapiens)6480464CTDTestosterone results in increased activity of HSD11B1 proteinPMID:20410225
Hsd11b1increases expressionISOHSD11B1 (Homo sapiens)6480464CTDTestosterone results in increased expression of HSD11B1 mRNAPMID:20410225
Hsd11b1multiple interactionsISOHSD11B1 (Homo sapiens)6480464CTD[Testosterone co-treated with NAD] binds to HSD11B1 protein; Testosterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]PMID:25526675 PMID:28257955
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