GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fshb | affects expression | EXP | | 6480464 | CTD | Testosterone affects the expression of FSHB protein | PMID:10709760 | Fshb | increases expression | EXP | | 6480464 | CTD | Testosterone results in increased expression of FSHB mRNA | PMID:16675544 | Fshb | multiple interactions | EXP | | 6480464 | CTD | [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA; [FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA; Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Tretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]] | PMID:22285649 | Fshb | decreases expression | ISO | Fshb (Rattus norvegicus) | 6480464 | CTD | Testosterone results in decreased expression of FSHB protein | PMID:2502373 PMID:2612737 | Fshb | decreases secretion | ISO | FSHB (Homo sapiens) | 6480464 | CTD | Testosterone results in decreased secretion of FSHB protein | PMID:16318399 | Fshb | increases expression | ISO | Fshb (Rattus norvegicus) | 6480464 | CTD | Testosterone results in increased expression of FSHB protein | PMID:10100480 | Fshb | increases secretion | ISO | FSHB (Homo sapiens) | 6480464 | CTD | FSHB protein results in increased secretion of Testosterone | PMID:15781295 | Fshb | multiple interactions | ISO | Fshb (Rattus norvegicus) | 6480464 | CTD | 1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; 1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; 1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]; [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]]; [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone results in increased phosphorylation of and results in increased activity of RAF1 protein]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; FSHB protein inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]]; FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of and results in increased activity of RAF1 protein]; FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]; FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]; FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; Testosterone inhibits the reaction [LHRH, Leu(6)-des-Et-GlyNH2(10)- results in increased secretion of FSHB protein]; Testosterone promotes the reaction [FSHB results in increased expression of CYP11A1 mRNA]; Testosterone promotes the reaction [FSHB results in increased expression of CYP19A1 mRNA] | PMID:16574160 PMID:21177760 PMID:21273442 PMID:6783399 | Fshb | multiple interactions | ISO | FSHB (Homo sapiens) | 6480464 | CTD | [CGA protein co-treated with FSHB protein] affects the abundance of Testosterone; [FSHB protein co-treated with LHB protein co-treated with CGB3 protein] results in increased abundance of Testosterone; [FSHB protein co-treated with testosterone enanthate] results in increased abundance of Testosterone; [FSHB protein co-treated with Testosterone] results in decreased expression of AKAP12 mRNA; [FSHB protein co-treated with Testosterone] results in decreased expression of CAV1 mRNA; [FSHB protein co-treated with Testosterone] results in decreased expression of CAV2 mRNA; [FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Cyclic AMP; [FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Estradiol; [FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Progesterone; [FSHB protein co-treated with Testosterone] results in increased expression of AREG mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of CA2 mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of CYP11A1 mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of HSD3B1 mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of INHA mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of INHBA mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of PDE4B mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of SGK1 mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of SNAP25 mRNA; [FSHB protein co-treated with Testosterone] results in increased expression of STAR mRNA; FSHB protein promotes the reaction [CGA protein results in increased secretion of Testosterone]; FSHB protein promotes the reaction [CGB3 protein results in increased abundance of Testosterone]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Estradiol]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Progesterone] | PMID:18535249 PMID:19228890 PMID:22451503 PMID:7655650 PMID:8263139 | | ||||||||||||||||||||||
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