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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fth1
Name: ferritin heavy chain 1
Acc ID: CHEBI:173086
Term: ferrostatin-1
Definition: An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.
Chemical ID: MESH:C573944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fth1multiple interactionsEXP 6480464CTDferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein]PMID:33737050
Fth1multiple interactionsISOFth1 (Mus musculus)6480464CTDferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTH1 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FTH1 protein]PMID:34863575 PMID:34864093 PMID:35608139 PMID:35661779 PMID:36435477
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