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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736217
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2D6
Name: cytochrome P450 family 2 subfamily D member 6
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2D6affects chemical synthesisEXP 6480464CTDCYP2D6 protein affects the chemical synthesis of MorphinePMID:15625333
CYP2D6multiple interactionsEXP 6480464CTD[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of MorphinePMID:16595712 PMID:21241245
CYP2D6increases activityISOCyp2d22 (Mus musculus)6480464CTDMorphine results in increased activity of CYP2D6 proteinPMID:35914676
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