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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62217
Species: Mus musculus
RGD Object: Gene
Symbol: Aif1
Name: allograft inflammatory factor 1
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aif1increases expressionEXP 6480464CTDMorphine results in increased expression of AIF1 proteinPMID:37394652
Aif1multiple interactionsEXP 6480464CTDcorilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]PMID:37394652
Aif1multiple interactionsISOAif1 (Rattus norvegicus)6480464CTD[lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNAPMID:26478469
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