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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349499
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A6
Name: UDP glucuronosyltransferase family 1 member A6
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A6increases glucuronidationEXP 6480464CTDUGT1A6 protein results in increased glucuronidation of MorphinePMID:12920162
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