Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDMorphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A proteinPMID:15497504 PMID:23056601
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTDNaloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]PMID:15497504
Go Back to source page   Continue to Ontology report