GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | increases hydroxylation | EXP | | 6480464 | CTD | CYP2E1 protein results in increased hydroxylation of aniline | PMID:18038910 PMID:18291569 PMID:18436364 | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | caffeic acid phenethyl ester inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]; Changkil inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]; puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline] | PMID:18038910 PMID:18291569 PMID:18436364 | Cyp2e1 | decreases activity | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | aniline results in decreased activity of CYP2E1 protein | PMID:12814958 PMID:15306208 | Cyp2e1 | increases hydroxylation | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | CYP2E1 protein results in increased hydroxylation of aniline | PMID:8858968 PMID:9195021 | Cyp2e1 | increases hydroxylation | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | CYP2E1 protein results in increased hydroxylation of aniline | PMID:23274713 | Cyp2e1 | increases metabolic processing | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | CYP2E1 protein results in increased metabolism of aniline | PMID:12464242 PMID:8819299 | Cyp2e1 | increases metabolic processing | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | CYP2E1 protein results in increased metabolism of aniline | PMID:26463279 | Cyp2e1 | multiple interactions | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | CYP2E1 protein affects the metabolism of [norharman co-treated with aniline]; Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of aniline]; Proadifen inhibits the reaction [CYP2E1 protein results in increased metabolism of aniline] | PMID:15279827 PMID:8074729 PMID:8819299 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of aniline; [Grape Seed Proanthocyanidins results in decreased activity of CYP2E1 protein] which results in decreased hydroxylation of aniline; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of aniline]; Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]; Genistein inhibits the reaction [Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]] | PMID:11330834 PMID:23274713 PMID:8117321 PMID:9010585 | | ||||||||||||||||||||||
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