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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352888
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C3
Name: aldo-keto reductase family 1 member C3
Acc ID: CHEBI:17263
Term: estrone
Definition: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Chemical ID: MESH:D004970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C3increases metabolic processingEXP 6480464CTDAKR1C3 protein results in increased metabolism of EstronePMID:19010312
AKR1C3increases reductionEXP 6480464CTDAKR1C3 protein results in increased reduction of EstronePMID:20036328
AKR1C3multiple interactionsEXP 6480464CTD[AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol; [AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of EstradiolPMID:19010312 PMID:20036328
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