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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304603
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrf1
Name: nuclear respiratory factor 1
Acc ID: CHEBI:17245
Term: carbon monoxide
Definition: A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Chemical ID: MESH:D002248
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrf1increases expressionEXP 6480464CTDCarbon Monoxide results in increased expression of NRF1 proteinPMID:17179207
Nrf1multiple interactionsEXP 6480464CTD1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]PMID:17179207
Nrf1increases expressionISONrf1 (Mus musculus)6480464CTDCarbon Monoxide results in increased expression of NRF1 mRNAPMID:17179207
Nrf1increases localizationISONrf1 (Mus musculus)6480464CTDCarbon Monoxide results in increased localization of NRF1 proteinPMID:18845810
Nrf1multiple interactionsISONrf1 (Mus musculus)6480464CTDAKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]PMID:18845810
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