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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases phosphorylationEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in decreased phosphorylation of GSK3B proteinPMID:37364752
Gsk3bdecreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased phosphorylation of GSK3B proteinPMID:31228551
Gsk3bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTDmono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of GSK3B protein]PMID:28526321
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD[mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of GSK3B protein; RBP4 protein promotes the reaction [[mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of GSK3B protein]; RBP4 protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of GSK3B protein]PMID:31228551
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