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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731946
Species: Mus musculus
RGD Object: Gene
Symbol: Ppard
Name: peroxisome proliferator activator receptor delta
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppardmultiple interactionsEXP 6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of PPARD mRNAPMID:31884101
Ppardaffects bindingISOPPARD (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate binds to PPARB proteinPMID:23843199
Ppardaffects expressionISOPpard (Rattus norvegicus)6480464CTDmono-(2-ethylhexyl)phthalate affects the expression of PPARD mRNA; mono-(2-ethylhexyl)phthalate affects the expression of PPARD proteinPMID:15647598
Ppardincreases activityISOPPARD (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased activity of PPARD proteinPMID:27551952
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