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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Staraffects expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate affects the expression of STARPMID:19560483
Stardecreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of STAR mRNAPMID:16809437 PMID:30476341
Starincreases activityEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased activity of STAR proteinPMID:22525294
Starincreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of STAR mRNAPMID:16809437 PMID:22087261
Starmultiple interactionsEXP 6480464CTDmono-(2-ethylhexyl)phthalate promotes the reaction [Tretinoin results in decreased expression of STAR mRNA]PMID:30476341
Stardecreases expressionISOStar (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of STAR mRNAPMID:22401849
Stardecreases expressionISOSTAR (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of STAR mRNAPMID:22401849
Starincreases expressionISOStar (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of STAR mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of STAR proteinPMID:25677926 PMID:27181934 PMID:30648648
Starmultiple interactionsISOStar (Mus musculus)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of STAR mRNA; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of STAR protein]; Genistein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of STAR mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [LHB protein results in increased expression of STAR protein]PMID:27181934 PMID:30648648 PMID:31884101 PMID:34627990
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