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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of BAX proteinPMID:37286014 PMID:37979351
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of BAX proteinPMID:12927354 PMID:24706461 PMID:26597031 PMID:33159713
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of BAX mRNA; epigallocatechin gallate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein]; GW 6471 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein]PMID:31884101 PMID:37286014 PMID:37979351
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with monobutyl phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of BAX mRNAPMID:35861251
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