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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc7a11
Name: solute carrier family 7 member 11
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc7a11decreases expressionISOSLC7A11 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of SLC7A11 proteinPMID:36438553
Slc7a11increases expressionISOSLC7A11 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 mRNAPMID:24356939 PMID:36695872
Slc7a11increases expressionISOSlc7a11 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 proteinPMID:34863575
Slc7a11multiple interactionsISOSLC7A11 (Homo sapiens)6480464CTDRSL3 compound promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of SLC7A11 protein]PMID:36438553
Slc7a11multiple interactionsISOSlc7a11 (Mus musculus)6480464CTDferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 protein]; HIF1A gene mutant form inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 protein]PMID:34863575
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